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Endocrine Abstracts

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ea0084op-01-01 | Oral Session 1: Topic Highlights | ETA2022

Cryo-electron microscopy structure of full length TSH receptor in complex with TSH receptor blocking human monoclonal autoantibody K1-70TM

Nunez Miguel Ricardo , Sanders Paul , Allen Lloyd , Evans Michele , Holly Matthew , Johnson William , Sullivan Andrew , Miller-Gallacher Jennifer , Sanders Jane , Furmaniak Jadwiga , Rees Smith Bernard

Objectives: The crystal structures of the TSH receptor (TSHR) leucine rich repeat domain (LRD) bound to TSHR stimulating monoclonal autoantibody M22TM or to TSHR blocking monoclonal autoantibody K1-70TM and antibody free have been solved previously. Cryo-electron microscopy (cryo-EM) was now used to solve the structure of full length TSHR in complex with K1-70TM.Methods: Recombinant human TSHR expressed in CHO cells was i...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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